Understanding the Key Differences Between Semaglutide and Tirzepatide

What is Semaglutide?

Semaglutide is a compounded version of the hormone glucagon-like peptide-1 (GLP-1). It is used for weight management in people with obesity. This medication works by:

• Boosting insulin secretion when blood sugar levels are high.

• Slowing gastric emptying, which helps patients feel fuller for longer.

  
  

Clinical studies have shown that individuals using Semaglutide can experience an average weight loss of about 15% of their body weight, alongside improvements in their blood sugar control.

What is Tirzepatide?

Tirzepatide is a newer medication that not only acts on GLP-1 but also targets GIP (gastric inhibitory polypeptide) receptors. This dual action is believed to make Tirzepatide more effective in managing blood sugar and encouraging weight loss. Similar to Semaglutide, Tirzepatide is also a once-weekly injection.

In clinical trials, patients taking Tirzepatide have reported an average weight loss of around 20% of their body weight, which is reportedly higher than that seen with Semaglutide.

Side Effects and Considerations

Both Semaglutide and Tirzepatide share similar side effects, especially related to the gastrointestinal system, such as:

• Nausea

• Vomiting

• Diarrhea

  
  

However, some individuals do not experience any symptoms. It is important to voice health concerns to your provider.